Gay marriage supporters march in Calif, Utah

Thousands of protesters angered by the passage of a state measure banning gay marriage took to the streets Friday in San Francisco and Long Beach, while thousands more protested outside the headquarters of the Mormon church in Salt Lake City.

The marches were the latest of several demonstrations held throughout the state this week after the passage of Proposition 8, which would amend the California Constitution to define marriage as between a man and a woman. The measure overrides a state Supreme Court ruling in May that briefly gave same-sex couples the right to wed.

In Salt Lake City, a crowd of about 2,000 chanted "Separate church and state" and …

Stalled U.S. 35 project leaves couple in limbo: ; Pair say they have not received estimate for land along proposed route

A South Charleston couple said they are in limbo after the statebacked out of a deal to buy 92 acres of land from them to build thenow-stalled U.S. 35. The drama over how the state planned toconstruct the final 14.6-mile stretch of new four-lane highway inMason and Putnam counties took many twists and turns in the pastyear, going so far as the state Supreme Court. After a proposal toshore up the projects financing died in the Legislature in March,officials were forced to let the bid for construction expire,essentially killing the project for now. But that left stateofficials with another problem: What to do with all of the propertyalong that stretch that they had …

Peptide libraries--an enabling tool for screening applications: high throughput screening of peptide libraries is now affordable.(Biochemicals & Kits)

Peptide libraries have long been shunned as drug discovery tools, as production costs were often prohibitive and development tools, such as public databases or algorithms for epitope mapping, were not readily available.

These limitations have been overcome, and screening of peptide libraries is now affordable. This article summarizes examples in which peptide libraries (1) have been used in enzymatic substrate screening, and in vaccine and gene therapy research.

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High throughput screening of peptide substrates for tyrosine kinases(2)

Protein tyrosine kinases (PTKs) are involved in a variety of signaling pathways, such as those regulating cell proliferation, differentiation and death. Identifying the substrates of kinases is of prime importance in understanding cellular machinery.

Potential substrates for a range of 39 pharmaceutically relevant PTKs were identified using public databases (Phospho.ELM and Phosphosite). The output sequences were optimized to generate 13-mer peptides covering the potential phosphorylation sites, …

SKIDMORE GOLF COACH GETS BIG HONOR.(SPORTS)

Byline: Sean Martin

Under head coach Tim Brown's guidance, the Skidmore College golf team has earned the reputation of being one of the elite programs in the Northeast.

That reputation and the success of the Thoroughbreds on the links has not gone unnoticed, and Brown was recently bestowed an impressive personal honor.

Brown was named as the lone assistant coach for a team consisting of 12 college players representing the United States in a tournament in Japan in late June. The tournament is being sponsored by the Nippon Sports Society of Japan. When and where the team will play has yet to be determined.

The selection came as a …

National Football League Standings

W L T Pct PF PA

x-New England 13 0 0 1.000 503 222

Buffalo 7 6 0 .538 222 291

N.Y. Jets 3 10 0 .231 239 315

Miami 0 13 0 .000 213 355

South

W L T Pct PF PA

y-Indianapolis 11 2 0 .846 381 217

Jacksonville 9 4 0 .692 305 229

Tennessee 7 6 0 .538 249 264

Houston 6 7 …

County League gets underway.

Cricketers in action on Sunday

FIXTURES FOR SUNDAY, MAY 6

BEDFORDSHIRE COUNTY LEAGUE

Premier Division

Biggleswade Town v Flitwick

Ickwell v Clifton

Sharnbrook v Dunstable

Vauxhall Motors v Luton Town & Indians

First Division

Dunstable 2 v Harrold

Eggington Foresters v Kempston Hammers

Leighton Buzzard Town v Vauxhall Motors 2

Southill Park v Ickwell 2 …

A tough time for comics with Obama as president?

Where's the funny in Barack Obama?

That question, which dogged TV humorists throughout the presidential race, has gained new urgency now that Obama is headed for the White House.

His victory last week signaled imminent hardship for comics who lampoon political leaders for a living. The laugh-a-minute 2008 campaign is history, and soon there'll be no President George W. Bush to kick around in comedy sketches or talk-show monologues.

Adding to the jesters' plight: Obama will soon be sworn in as the next Punch-Line-In-Chief.

Here is a man who inspires admiration, excitement or, maybe, suspicion. What he doesn't inspire (in any measurable …